Title

Cholera host response gene networks: preliminary studies

Authors

Paul Shapshak^1*, Charurut Somboonwit^{1, 2,} Shu Cao¹, John T. Sinnott^{1, 2}

Affiliation

¹Division of Infectious Diseases and International Medicine, Department of Internal Medicine, Morsani College of Medicine, Tampa, FL 33606 USA;

²Clinical Research Unit, Hillsborough Health Department, Tampa, Florida 33602;

Email

pshapshak@gmail.com

Article Type

Hypothesis

Date

Received October 24, 2017; Accepted October 24, 2017; Published October 31, 2017

Gene network analysis was performed based on published literature describing genes that are possibly interconnected with cholera vaccine responses in vitro in cell culture and in vivo in human patient punch biopsies as well as DNA extracted from blood. These studies produced divergent results. The differences should be replicated and studied further. Included in such studies, patient ethnicities, states of stress, nutrition, and health, as well as the precise characteristics of the various cholera vaccines and modes of delivery need to be considered as well.

Keywords

Cholera, gene networks, in vitro, in vivo, vaccines.

Citation

Shapshak et al. Bioinformation 13(10): 347- 351(2017)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.