Title

Lubricin: A Principal Modulator of the Psychoneuroendocrine - Osteoimmune Interactome – Implications for Novel Treatments of Osteoarthritic Pathologies

Authors

Allen Khakshooy^{1, 4} Nicole Balenton^{1, 3} Francesco Chiappelli^{1, 2, 3}

Affiliation

¹Laboratory of Human Psychoneuroendocrine-Osteoimmunology; School of Dentistry, UCLA Center for the Health Sciences, Los Angeles, CA 90095-1668;

²Evidence-Based Decision Practice-Based Research Network, DGSO, Los Angeles, CA 91403;

³Department of the Health Sciences, CSUN, Northridge, CA 91330;

⁴Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel 3109601;

Email

fchiappelli@dentistry.ucla.edu

Article Type

Hypothesis

Date

Received October 5, 2017; Accepted October 5, 2017; Published October 31, 2017

Lubricin is a synovial glycoprotein that contributes to joint lubrication. We propose the hypothesis that lubricin is a key modulator of the psychoneuroendocrine-osteoimmune interactome, with important clinical relevance for osteoarthritic pathologies. We consider a variety of neuroendocrine-immune factors, including inflammatory cytokines and chemokines that may contribute to the modulation of lubricin in rheumatic complications. Based on our preliminary immunocytochemistry and fractal analysis data, and in the context of translational research of modern healthcare, we propose that molecular lubricin gene expression modification by means of the novel CRISPR/Cas system be considered for osteoarthritic therapies.

Keywords

Lubricin, interactome, osteoimmunology, psychoneuroendocrine-osteoimmunology, osteoarthritis, CRISPR

Citation

Khakshooy et al. Bioinformation 13(10): 343-346 (2017)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.