Title

Authors

Affiliation

Department of Genetic Engineering & Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong -4331, Bangladesh.

Email

adnan_orko@yahoo.com; *Corresponding author

Article Type

Hypothesis

Date

Received October 26, 2012; Accepted January 15, 2013; Published February 21, 2013

Staphylococcus aureus is a gram positive bacterium, responsible for both community-acquired and hospital-acquired infection, resulting in a mortality rate of 39%. 43.2% resistance to methicilin and emerging resistance to Fluroquinolone and Oxazolidinone, have evoked the necessity of the establishment of alternative and effective therapeutic approach to treat this bacteria. In this computational study, various database and online software are used to determine some specific targets of Staphylococcus aureus N315 other than those used by Penicillin, Quinolone and Oxazolidinone. For this purpose, among 302 essential proteins, 101 non-homologous proteins were accrued and 64 proteins which are unique in several metabolic pathways of S. aureus were isolated by using metabolic pathway analysis tools. Furthermore, 7 essentially unique enzymes involved in exclusive metabolic pathways were revealed by this research, which can be potential drug target. Along with these important enzymes, 15 non-homologous proteins located on membrane were identified, which can play a vital role as potential therapeutic targets for the future researchers.

Keywords

Staphylococcus aureus, Essential proteins, Surface, Therapeutic targets.

Citation

Hossain et al.  Bioinformation 9(4): 187-192 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.