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Title

Prevalence of hyperhomocysteinemia in healthy Indian doctors

 

Authors

Sandesh P Kamdi1* & Prashant Palkar2

 

Affiliation

1Medical Advisor, Akumentis Healthcare Ltd., 204, Second floor, G. Corp Tech Park, Kasarvadavali, Near Hyper City, Ghodbunder Road, Thane (W), 400 615, Maharashtra, India; 2Head Medical Services, Akumentis Healthcare Ltd., 204, Second floor, G. Corp Tech Park, Kasarvadavali, Near Hyper City, Ghodbunder Road, Thane (W), 400 615, Maharashtra, India.

 

Email

sandeshk@myakumentis.com; *Corresponding authors

 

Article Type

Hypothesis

 

Date

Received January 16, 2013; Accepted January 29, 2013; Published February 21, 2013

 

Abstract

Currently, hyperhomocysteinemia is a well-known risk factor for variety of vascular diseases. Prevalence of hyperhomocysteinemia increases with age. Hence, the present study was aimed to investigate the prevalence of hyperhomocysteinemia in healthy upper socio-economic class population in India. Total homocysteine (tHcy) concentration was determined in 1243 (906 men & 337 women) healthy Indian doctors with different age group. Using Third National Health and Nutrition Examination Survey (NHANES III) study criteria, the prevalence of hyperhomocysteinemia was 92.85% among men (>11.4 Ámol/L) and 81.60% among women (>10.4 Ámol/L). The prevalence of hyperhomocysteinemia was higher among men with mean tHcy concentration (21.96 ▒ 0.38 Ámol/L) significantly higher (P<0.0001) than women (15.90 ▒ 0.39 Ámol/L) (95% CI, 4.733-7.376). Our study showed very high prevalence of hyperhomocysteinemia which may point to the future risk for various pathologies in the present subset of population. Further studies to look at the plasma levels of homocysteine lowering vitamins are warranted to prevent the future risk of vascular diseases.

 

Keywords

Homocysteine, Hyperhomocysteinemia, Prevalence.

 

Citation

Kamdi & Palkar,  Bioinformation 9(4): 193-196 (2013)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.