Title
Effect of autologous platelet concentrates on osteoblast cell activity during early osseointegration
Authors
J.P. Mohan Raj1,*, P. Aarani2, Johnson Raja James1, Jacob Raja1, S. Divya1 & M. Thamilselvan1
Affiliation
1Department of Periodontology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India; 2Department of Prosthodontist, Private Practitioner, Tamil Nadu, India; *Corresponding author
J.P. Mohan Raj - E - mail: drjpmohanraj@gmail.com
P. Aarani - E - mail: aaranisathiyabama@gmail.com
Johnson Raja James - E - mail: viceprincipal@rajasdentalcollege.com
Jacob Raja - E - mail: chairman@rajasdentalcollege.com
S. Divya - E - mail: divyalal39@gmail.com
M. Thamilselvan - E - mail: thamil3011@gmail.com
Article Type
Research Article
Date
Received March 1, 2025; Revised March 31, 2025; Accepted March 31, 2025, Published March 31, 2025
Abstract
Advances in implant dentistry focuses on enhancing the predictability of implant success using advanced regenerative techniques. Autologous platelet concentrates rich in growth factors play a crucial role in stimulating osteoblast activity and improving osseointegration at implant sites. Therefore, it is of interest to evaluate the osteogenic efficacy of four injectable platelet concentrates: (1) injectable-platelet-rich fibrin, (2) leukocyte platelet-rich fibrin, (3) advanced platelet-rich fibrin and (4) Advanced platelet-rich fibrin + on titanium surfaces. All tested concentrates enhanced osteoblastic adhesion, differentiation and mineralization, with injectable-platelet-rich fibrin demonstrating the most significant calcium nodule formation. Thus, injectable-platelet-rich fibrin proved to be the most effective in promoting early osseointegration compared to the other platelet-rich fibrin types.
Keywords
Osseointegration, autologous platelet concentrates, platelet rich fibrin, growth factors, biomaterials in implantology
Citation
Raj et al. Bioinformation 21(3): 441-446 (2025)
Edited by
Neelam Goyal & Shruti Dabi
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
