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Title

Antifungal drug resistance pattern of Candida. spp isolated from vaginitis in Ilam-Iran during 2013-2014

 

Authors

Jasem Mohamadi1, Mohamad Reza Havasian2, Jafar Panahi2 & Iraj Pakzad3, 4*

 

Affiliation

1Department pediaterics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran; 2Department of Periodontics, School of Dentistry, Ilam University of Medical sciences, Ilam/ Iran; 3Department Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran; 4Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam/ Iran

 

Email

havasian@yahoo.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received February 26, 2015; Revised April 01, 2015; Accepted April 15, 2015; Published April 30, 2015

 

Abstract

Vaginal Candidiasis is the most common and important opportunistic fungal infection in women. By increasing use of antifungal drugs in recent years, it has caused drug resistance. This study aims to evaluate antifungal drugs susceptibility of Candida. spp isolated of women with vaginitis from Ilam-Iran during 2013-2014. samples were collected and cultured from 385 women with vaginitis, then Candida.spp was diagnosed by standard method. Antifungal drug susceptibility test for nystatin 100 unit/disk, fluconazole 10μg/disk, itraconazole 10μg/disk, ketoconazole 10μg/disk, amphotericinB 20μg/disk, clotrimazole 10μg/disk, posaconazole 5μg/disk, and voriconazole 1μg/disk were carried out by M44-A method(CLSI). From all culture positive samples, 150 isolates were Candida albicans and 89 isolates were non-albicans. The resistance to fluconazole, itraconazole, ketoconazole, clotrimazole, voriconazole, posaconazole, nystatin and amphotericin B was 76%, 62%, 72%, 55%, 6%, 7%, 1% and 0%. The highest resistance was seen for fluconazole , itraconazole, and the highest susceptible was seen for nystatin and amphotericin B. These results indicate nystatin and amphotericin B can be used as the first line for empirical therapy of vaginal candidiasis in the district.

 

Keywords

Drug resistance, Candida albicans, vaginitis.

 

Citation

Mohamadi et al. Bioinformation 11(4): 203-206 (2015)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.