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Title |
Molecular docking of selected phytocompounds with H1N1 proteins |
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Authors |
Mohammed I Alhazmi |
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Affiliation |
Dept. of Food Sciences and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh-11451, KSA
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malhazmi@ksu.edu.sa; *Corresponding author
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Article Type |
Hypothesis
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Date |
Received March 03, 2015; Revised March 13, 2015; Accepted March 23, 2015; Published April 30, 2015
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Abstract |
The H1N1 influenza virus is a serious threat to human population. Oseltamivir and Zanamivir are known antiviral drugs for swine flu with observed side effects. These drugs are viral neuraminidase and hemagglutinin inhibitor prevents early virus multiplication by blocking sialic acid cleavage on host cells. Therefore, it is of interest to identify naturally occurring novel compounds to control viral growth. Thus, H1N1 proteins (neuraminidase and hemagglutinin) were screened with phytocompounds isolated from Tulsi plant (Ocimum sanctum L.) using molecular docking tools. This identified Apigenin as an alternative to Oseltamivir and Zanamivir with improved predicted binding properties. Hence, it is of interest to consider this compound for further in vitro and in vivo evaluation.
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Keywords |
Swine Flu, H1N1, Docking, ADMET.
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Citation |
Alhazmi et al.
Bioinformation 11(4): 196-202 (2015) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |