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Reliability of Quality Assessments in Research Synthesis: Securing the Highest Quality Bioinformation for HIT



Francesco Chiappelli1, 2*, André Barkhordarian, C Phil1, 2, Rashi Arora1, 2, Linda Phi1, 2, Amy Giroux1, 2, Molly Uyeda1, 2, Jason Kung2, 3 & Manisha Ramchandani1, 2



1Division of Oral Biology & Medicine, UCLA School of Dentistry, Los Angeles, CA 90095-1668; 2Evidence-Based Study Group, EBD-Practice-Based Research Network; 3Zen Dental Center - Private Practice, Campbell, CA


Email; *Corresponding author


Article Type

Current Trends


Received June 30, 2012; Accepted July 06, 2012; Published July 21, 2012



Current trends in bio-medicine include research synthesis and dissemination of bioinformation by means of health (bio) information technology (H[b] IT). Research must secure the validity and reliability of assessment tools to quantify research quality in the pursuit of the best available evidence. Our concerted work in this domain led to the revision of three instruments for that purpose, including the stringent characterization of inter-rater reliability and coefficient of agreement. It is timely and critical to advance the methodological development of the science of research synthesis by strengthening the reliability of existing measure of research quality in order to ensure H[b] IT efficacy and effectiveness.



Health (bio) information technology (H[b] IT), research quality validation, reliability, acceptable sampling analysis, efficacy, effectiveness



Chiappelli et al. Bioinformation 8(14): 691-694 (2012)

Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.