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Title |
Internal force field in proteins seen by divergence entropy |
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Authors |
Damian Marchewka1, 2, Mateusz Banach1, 2, Irena Roterman1* |
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Affiliation |
1Department of Bioinformatics and Telemedicine, Jagiellonian University, Medical College Krakow, Poland; 2Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Krakow, Poland
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myroterm@cyf-kr.edu.pl; *Corresponding author
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Article Type |
Hypothesis
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Date |
Received May 28, 2011; Accepted June 27, 2011; Published July 06, 2011
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Abstract |
The characteristic distribution of non-binding interactions in a protein is described. It establishes that hydrophobic interactions can be characterized by suitable 3D Gauss functions while electrostatic interactions generally follow a random distribution. The implementation of this observation suggests differentiated optimization procedure for these two types of interactions. The electrostatic interaction may follow traditional energy optimization while the criteria for convergence shall measure the accordance with 3-D Gauss function.
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Citation |
Marchewka et al.
Bioinformation 6(8): 300-302 (2011) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |