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Title |
Annotation of hypothetical proteins orthologous in Pongo abelii and Sus scrofa |
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Authors |
Singh Jitendra1, Ranjana Narula2*, Shefali Agnihotri2, Maneet Singh1 |
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Affiliation |
1Department of Bioinformatics, ADI Biosolution, Mohali, Punjab, India 160059; 2Department of Bioinformatics, Hans Raj Mahila Mahavidyalaya, Jalandhar, Punjab, India
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narula.ranjana@gmail.com; *Corresponding author
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Phone |
+91-8054235713
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Article Type |
Hypothesis
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Date |
Received April 27, 2011; Accepted June 24, 2011; Published July 06, 2011
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Abstract |
A hypothetical protein is predicted to be expressed from an open reading frame without known experimental evidence of translation. They constitute a substantial fraction of proteomes. Domain extraction from these hypothetical sequences helps to search for protein coding genes for protein structural and functional annotation. We describe the analysis of prediction data in a sequence dataset of hypothetical protein orthologs of Pongo abelii (orangutan) and Sus scrofa (pig). It should be noted that these orangutan-pig orthologs are also non-homologous to human proteins. These predicted data find application in the genome wide annotation of proteins in poorly understood genomes.
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Keywords |
Pongo abelii, Sus scrofa, hypothetical proteins, functional annotation, structure prediction, subcellular localization.
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Citation |
Jitendra et al.
Bioinformation 6(8): 297-299 (2011) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |