Title

Linking common non-coding RNAs of human lung cancer and M. tuberculosis

Authors

Debmalya Barh^1,2,3*, Sandeep Tiwari², Ranjith N. Kumavath⁴, Preetam Ghosh⁵, Vasco Azevedo²

Affiliation

¹Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India;

²Laboratório de Genética Celular e Molecular, Departamento de Biologia Geral, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais, Pampulha, Belo Horizonte, Minas Gerais, Brazil;

³Division of Bioinformatics and Computational Genomics, NITTE University Center for Science Education and Research (NUCSER), NITTE (Deemed to be University), Deralakatte, Mangaluru, Karnataka, Índia;

⁴Department of Genomic Science, school of Biological Sciences, Central University of Kerala, Tejaswini Hills, Periya (P.O) Kasaragod, Kerala-671316, India;

⁵Department of Computer Science, Virginia Commonwealth University, Virginia 23284, USA;

Email

dr.barh@gmail.com;

Article Type

Hypothesis

Date

Received June 25, 2018; Revised June 26, 2018; Accepted June 30, 2018; Published June 30, 2018

Lung cancer and pulmonary tuberculosis caused by Mycobacterium are two major causes of deaths worldwide. Tuberculosis linked lung cancer is known. However, the precise molecular mechanism of Mycobacterium associated increased risk of lung cancer is not understood. We report 45 common human miRNAs deregulated in both pulmonary tuberculosis and lung cancer. We show that sRNA_1096 and sRNA_1414 from M. tuberculosis have sequence homology with human mir-21. Hence, the potential role of these three small non-coding RNAs in rifampicin resistance in pulmonary tuberculosis is implied. Further, the linking of sRNA_1096 and sRNA_1414 from M. tuberculosis with the host lung tumorigenesis is inferred. Nonetheless, further analysis and validation is required to associate these three non-coding RNAs with Mycobacterium associated increased risk of lung cancer.

Keywords

Genetic predisposition; lung cancer risk; microRNA; Mycobacterium tuberculosis, sRNA

Citation

Barh et al. Bioinformation 14(6): 337-345 (2018)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.