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Title

Binding property of HIV p24 and Reverse transcriptase by chalcones from Pongamia pinnata seeds

 

Authors

Manikannan Mathaiyan1, Arumugam Suresh1*, Rangasamy Balamurugan2

 

Affiliation

1Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai-600 119;

2Central Research Laboratory, Sri Manakula Vinayagar Medical College & Hospital, Madagadipet, Puducherry- 605107;

 

Email

kpm_suresh@yahoo.com

 

Article Type

Hypothesis

 

Date

Received April 10, 2018; Revised June 8, 2018; Accepted June 8, 2018; Published June 30, 2018

 

Abstract

HIV remains a challenging life threatening viral agent for humans despite available anti HIV drugs. The known effective drug named HAART clears the circulating viruses but not the intracellular viruses. Therefore, it is of interest to identify molecules with improved anti-HIV activity from natural plant sources. Hence, we studied the anti-HIV potency of an Indian medicinal plant named Pongamia pinnata. Aqueous extracts were made from leaf, seed and roots of Pongmia pinnata and screened for anti HIV-1 activity using HIV-1 p24 and reverse transcriptase (RT) inhibition assays. Further, the active chalcone derivatives namely, P24 protein and RT enzymes showed promising binding score against Glabarachalcone and Karanijin. Among these extracts, P. pinnta aqueous seed extracts have shown HIV-1 p24 inhibition at 66.9 4.4 percentage. However, RT inhibition assay showed only 36.8%. Hence, the HIV-1 p24 inhibition infers either the prevention of virus entry or inhibits other enzymes and or interferes with virion assembly.

 

Keywords

HIV; Pongamania pinnata; chalcones; Glabarachalcone; karanijin; P24 protein; Reverese transcriptase

 

Citation

Mathaiyan et al. Bioinformation 14(6): 279- 284 (2018)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.