|
Title |
Prediction aided In vitro analysis of octadecanoic acid from cyanobacterium Lyngbya sp. As a proapoptotic factor in eliciting anti-inflammatory properties
|
|
Authors |
Paramasivan Manivannan*, Gangatharan Muralitharan, Nainangu Prasanna Balaji
|
|
Affiliation |
1Department of Microbiology, Bharathidasan University, Tiruchirappalli - 620024, Tamilnadu, India;
|
|
|
|
|
Article Type |
Hypothesis
|
|
Date |
Received August 2, 2017; Accepted August 8, 2017; Published September 30, 2017
|
|
Abstract |
Marine Lyngbya has been proven as a potent anticancer agent by disrupting microfilament network. Lyngbya and its associated cyanobacterial compounds have been stressed for futuristic advancements in cancer research and have foreseen explicit advancements in the recent era. Moreover, compounds like lyngbyabellins, lyngbyastatins and other derived toxins are significantly studied. Therefore it is of interest to study the efficacies of Lyngbya fatty acid derivatives. Cytotoxicity and DNA laddering studies proves the efficiency and safety of marine Lyngbya. Caspase – 3 along with MMP2 and MMP9 affirms the anti-inflammatory properties. Molecular docking shows that Octadecanoic acid has strong binding affinity to MMP-2. The role of octadecanoic acid as a proapoptotic factor in emancipation of inflammation apart from inducing apoptosis is of interest to study in future.
|
|
Keywords |
Lyngbya, octadecanoic acid, proapoptotic factor, anti-inflammatory activity, MMP-2, Interaction assessment.
|
|
Citation |
Manivannan et al. Bioinformation 13(9): 301-306 (2017)
|
|
Edited by |
P Kangueane
|
|
ISSN |
0973-2063
|
|
Publisher |
|
|
License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
|