Title

Docking Analysis of Verteporfin with WW Domain of YAP

Authors

Ilham Kandoussi¹, Wiam Lakhlili¹, Jamal Taoufik², Azeddine Ibrahimi¹

Affiliation

¹Laboratoire de Biotechnologie (MedBiotech), Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V Rabat, Morocco;

²Laboratoire de Chimie thérapeutique Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V Rabat, Morocco;

Email

ilham.kandoussi@hotmail.fr

Article Type

Hypothesis

Date

Received June 19, 2017; Revised July 7, 2017; Accepted July 8, 2017; Published July 31, 2017

The YAP oncogene is a known cancer target. Therefore, it is of interest to understand the molecular docking interaction of verteporfin (a derivative of benzo-porphyrin) with the WW domain of YAP (clinically used for photo-dynamic therapy in macular degeneration) as a potential WW domain-ligand modulator by inhibition. A homology protein SWISS MODEL of the human YAP protein was constructed to dock (using AutoDock vina) with the PubChem verteporfin structure for interaction analysis. The docking result shows the possibilities of verteporfin interaction with the oncogenic transcription cofactor YAP having WW1 and WW2 domains. Thus, the ability of verteporfin to bind with the YAP WW domain having modulator activity is implied in this analysis.

Keywords

Hippo, TEAD, YAP, kinase, vertoporphine, docking

Citation

Ilham Kandoussi et al. Bioinformation 13(7): 237-241 (2017)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.