Title

Functional prediction of hypothetical proteins in human adenoviruses

Authors

Shane Dorden & Padmanabhan Mahadevan* 

Affiliation

Department of Biology, University of Tampa, 401 W. Kennedy Blvd., Box 3F, Tampa, FL, 33606, USA

Email

pmahadevan@ut.edu;  *Corresponding author

Article Type

Hypothesis

Date

Received October 11, 2015; Accepted October 15, 2015; Published October 31, 2015

Assigning functional information to hypothetical proteins in virus genomes is crucial for gaining insight into their proteomes. Human adenoviruses are medium sized viruses that cause a range of diseases. Their genomes possess proteins with uncharacterized function known as hypothetical proteins. Using a wide range of protein function prediction servers, functional information was obtained about these hypothetical proteins. A comparison of functional information obtained from these servers revealed that some of them produced functional information, while others provided little functional information about these human adenovirus hypothetical proteins. The PFP, ESG, PSIPRED, 3d2GO, and ProtFun servers produced the most functional information regarding these hypothetical proteins.

Hypothetical protein; human adenovirus; pathogen; protein function prediction; web server

Citation

Dorden & Mahadevan Bioinformation 11(10): 466-473 (2015)
 

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.