Title

Authors

Affiliation

¹Bioinformatics Infrastructure Facility, Biotechnology Division, CSIR-North East Institute of Science and Technology, Jorhat, 785 006 Assam; ²Natural Product Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam; ³Centre for Bioinformatics Studies, Dibrugarh University, Dibrugarh, Assam.

Email

dhruba.bio.du@gmail.com; *Corresponding author

Article Type

Hypothesis

Date

Received August 25, 2012; Accepted September 03, 2012; Published September 11, 2012

Litsea spp of Laural family are traditionally used as herbal medicine for treating inflammation including gastroenterologia, oedema and rheumatic arthritis. Therefore, it is of interest to investigate and understand the molecular principles for such actions. Here, we have illustrated the binding of thirteen Litsea derived biologically active compounds against the inflammation associated target COX (cyclo-oxygenase) -2 enzymes. We compared the binding information of these compounds with a selected number of already known COX-2 inhibitors. The comparison reflected that some of these compounds such as linderol, catechin, 6'-hydroxy-2',3',4' - trimethoxy-chalcone and litseaone have better or equivalent binding features compared to already known inhibitory compounds namely celecoxib, acetylsalicylic acid, rofecoxib. Therefore, all these small compounds reported from plant Litsea spp were found to possess potential medicinal values with anti-inflammatory properties.

Keywords

COX-2 inhibitor, Litsea plant, inflammation, docking

Citation

Gogoi et al. Bioinformation 8(17): 812-815 (2012)
 

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.