Title

Authors

Affiliation

¹Masonic Cancer Center; ²Division of Basic and Translational Research, Department of Surgery, University of Minnesota, MN 55455

Email

subree@umn.edu; *Corresponding author

Article Type

Database

Date

Received July 27, 2012; Accepted July 28, 2012; Published August 03, 2012

A given mRNA can be regulated by interactions with miRNAs and in turn the availability of these miRNAs can be regulated by their interactions with alternate mRNAs. The concept of regulation of a given mRNA by alternate mRNA (competing endogenous mRNA) by virtue of interactions with miRNAs through shared miRNA response elements is poised to become a fundamental genetic regulatory mechanism. The molecular basis of the mRNA-mRNA cross talks is via miRNA response elements, which can be predicted based on both molecular interaction and evolutionary conservation. By examining the co-occurrence of miRNA response elements in the mRNAs on a genome-wide basis we predict competing endogenous RNA for specific mRNAs targeted by miRNAs. Comparison of the mRNAs predicted to regulate PTEN with recently published work, indicate that the results presented within the competing endogenous RNA database (ceRDB) have biological relevance.

Availbilty

http://www.oncomir.umn.edu/cefinder/

Keywords

ceRNAs, MRE, microRNA response elements, database, competing endogenous RNAs database, ceRDB

Citation

Sarver & Subramanian, Bioinformation 8(15): 731-733 (2012)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.