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Title

Carbon distribution to toxic effect in toxin proteins

 

Authors

Kannaiyan Akila2, Rajendran Kaliaperumal2 & Ekambaram Rajasekaran1*

 

Affiliation

1Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Karunya Nagar, Coimbatore 641114, Tamil Nadu, India; 2Department of Biotechnology, Periyar Maniammai University, Thanjavur 613403, Tamil Nadu, India.

 

Email

ersekaran@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received July 09, 2012; Accepted July 16, 2012; Published August 03, 2012

 

Abstract

The role of hydrophobic force in biological function through the formation of several local macro-molecular structures is evident. Carbon is the element that contributes to biological function in living systems. We show that carbon distribution is related to protein activity using an example. The carbon distribution profile is foreseen to help undestand unfolded and misfolded regions of protein structures. The carbon distribution profile in a toxin protein that is found associated with the toxic shock syndrome is described in this study. The carbon profile provides insight to the association of specific residues responsible for toxicity.

 

Keywords

carbon distribution, mutational study, hydrophobic interation, toxic protein, mitogenicity, carbon profile

 

Citation

Akila et al. Bioinformation 8(15): 720-721 (2012)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.