Structure based virtual screening of inhibitors for binding at the allosteric site of HCV RNA dependent RNA polymerase

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Title	Structure based virtual screening of inhibitors for binding at the allosteric site of HCV RNA dependent RNA polymerase
Authors	Amjesh Revikumar¹*, Achuthsankar Sukumaran Nair¹ & Sugunan Vetha Sundaram²
Affiliation	¹Centre for Bioinformatics, University of Kerala, Trivandrum 695581, India; ²Department of Zoology, His Highness The Maharaja's University College, Trivandrum, 695034, Kerala, India.
Email	amjesh@gmail.com; *Corresponding author
Article Type	Hypothesis
Date	Received December 11, 2011; Accepted December 22, 2011; Published August 03, 2012
Abstract	Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality. There is no effective treatment or prevention till date for HCV infection. We describe the computed binding of 10 compounds to the allosteric binding site of RNA dependent RNA polymerase enzyme. These compounds were identified from the ZINC database through virtual screening followed by ADMET evaluation.
Citation	*Revikumar et al.* Bioinformation 8(15): 716-719 (2012)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.