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Title

Antagomirbase: A putative antagomir database

 

Authors

Sayak Ganguli*, Sanga Mitra, Abhijit Datta

 

Affiliation

DBT-Centre for Bioinformatics, Presidency University, Kolkata 700073

 

Email

sayakbif@yahoo.com; *Corresponding author

 

Article Type

Database

 

Date

Received November 12, 2010; Accepted December 21, 2010; Published August 20, 2011

 

Abstract

The accurate prediction of a comprehensive set of messenger putative antagomirs against microRNAs (miRNAs) remains an open problem. In particular, a set of putative antagomirs against human miRNA is predicted in this current version of database. We have developed Antagomir database, based on putative antagomirs-miRNA heterodimers. In this work, the human miRNA dataset was used as template to design putative antagomirs, using GC content and secondary structures as parameters. The algorithm used predicted the free energy of unbound antagomirs. Although in its infancy the development of antagomirs, that can target cell specific genes or families of genes, may pave the way forward for the generation of a new class of therapeutics, to treat complex inflammatory diseases. Future versions need to incorporate further sequences from other mammalian homologues for designing of antagomirs for aid in research.

 

Availability

http://bioinfopresidencycollegekolkata.edu.in/antagomirs.html

 

Citation

Ganguli et al. Bioinformation 7(1): 41-43 (2011)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.