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Title |
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Decoding the differential biomarkers of Rheumatoid arthritis and Osteoarthritis: A functional genomics paradigm to design disease specific therapeutics |
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Authors |
Sreyasi Biswas1, Jayapal Manikandan2, Peter Natesan Pushparaj1* |
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Affiliation |
1Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, 120 University Place, University of Glasgow, Glasgow G12 8TA; 2Deaprtment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119745 |
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peter.n.pushparaj@gmail.com; *Corresponding author
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Article Type |
Hypothesis
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Date |
Received April 21, 2011; Accepted April 25, 2011; Published May 07, 2011 |
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Abstract |
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unidentified aetiology, chiefly affecting the synovial membranes of joints, cartilage, bone, bursa and tendon sheath. Osteoarthritis (OA) is a degenerative disorder and encompass different sets of pathogenic pathways than RA; however, it shows a medley of clinical manifestations or symptoms resembling RA. Hence, we intend to identify more disease specific biomarkers through the meta-analysis of microarray datasets that can be crucial in the differential diagnosis, disease specific treatment as well as management of both RA and OA in a typical clinical setting. |
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Keywords |
Rheumatoid Arthritis, Osteoarthritis, Synovial Membrane, Microarrays, Biomarkers. |
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Citation |
Biswas et al. Bioinformation 6(4): 153-157 (2011)
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Edited by |
P Kangueane |
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |