Title

The role of the microenvironment in tumor immune surveillance 

Authors

Oluwadayo Oluwadara¹, Luca Giacomelli², Xenia Brant^{1, 3}, Russell Christensen⁴, Raisa Avezova¹, George Kossan¹, Francesco Chiappelli^1*

Affiliation

¹School of Dentistry, Division of Oral Biology and Medicine; ²Tirrenian Stomatologic Institute, Lido di Camaiore (Lucca), Italy; ³CEO IPSEMG Belo Horizonte, Brazil; ⁴UCLA School of Dentistry, Division of Oral and Maxillofacial Pathology 

Email

fchiappelli@dentistry.ucla.edu

Article Type

Hypothesis

Date

Received July 25, 2010; Accepted August 03, 2010; Published January 06, 2011
 

The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O’Shea & Paul, 2010 ). To review the putative role of the microenvironment in modulating the commitment of tumor immune surveillance, we use the model of oral premalignant lesions.  

Keywords

Oral lichen planus, oral squamous cell carcinoma, proteomic voting, tumor microenvironment, T cell lineages, tumor immune surveillance

Citation

Oluwadara et al. Bioinformation 5(7): 285-290 (2011)

Edited by

Francesco chiappelli

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.