|
Title
|
|
A QSAR study on some series of anti-hepatitis B virus (HBV) agents |
|
Authors
|
Preet K. Arora, Vaishali M. Patil, Satya P. Gupta* | |
|
Affiliation
|
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut 250005, India
| |
|
|
| |
|
Article Type
|
Hypothesis | |
|
Date
|
Received February 02; accepted March 02, 2010; published March 31, 2010 | |
|
Abstract |
A quantitative structure-activity relationship (QSAR) study has been made on some series of anti-hepatitis B virus (HBV) agents, namely, a series of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine, a similar series of compounds comprising of 2- amino-6-arylthio-9-[2-(phosphonoethoxy)ethyl] purine bis(2,2,2- trifluoroethyl) esters, and a series of 1-isopropylsulfonyl-2-amine benzimidazoles. In each case significant correlations are found between the anti-HBV potencies and some physicochemical and steric properties of the compounds, indicating that for the first two series the activity is controlled by the hydrophobic and the bulk properties of the molecules and, for the third series, the steric and hydrogen bonding properties of compounds are crucial for their anti-HBV potency.
| |
|
Keywords |
QSAR study, anti-hepatitis B virus agents, hepatitis B virus inhibitors, bis(L-amino acid) ester prodrugs of 9-[2- (phosphonomethoxy)ethyl]adenine, 2-amino-6-arylthio-9-[2-(phosphonoethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) esters, 1-isopropylsulfonyl-2-amine benzimidazoles
| |
|
Citation
|
Arora et al., Bioinformation 4(9): 417-420 (2010)
| |
|
Edited by
|
P. Kangueane
| |
|
ISSN
|
0973-2063
| |
|
Publisher
|
||
|
License
|
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |