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Title
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Lysine richness in human snurps – possible sites for electrophilic attacks |
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Authors
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Sanjay Kumar Dey*, Sayak Ganguli, Protip Basu, Paushali Roy, Abhijit Datta | |
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Affiliation
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DBT-Centre for Bioinformatics, Presidency College, Kolkata | |
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Article Type
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Hypothesis | |
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Date
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Received September 10, 2009; accepted November 14, 2009; published March 31, 2010 | |
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Abstract |
Gene-expression strategies are remodeled following exposure to stress. The reactive oxidants and electrophiles generated after stress actually affects the structural and functional properties of different cellular proteins. It is also seen that lysine rich motifs of proteins play crucial role in electrophilic attack and modification. Therefore, this study revealing lysine richness in 5 main human snrups (Small Nuclear Ribonucleoproteins) indicates a possible mechanism of gene regulation under stress. This possibility is highly supported by the findings that surface residues of the molecules were full of lysine rich clusters. Lysine richness is also found to be a highly conserved pattern across the various domains of life indicative of stress adaptation in the prebiotic to biotic world transition. Moreover the modeled structures showed good all atom contacts and minimal outliers.
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Keywords |
Electrophiles, lysine, gene regulation, oxidative stress, snurps.
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Citation
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Dey et al., Bioinformation 4(9): 409-411 (2010) | |
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Edited by
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P. Kangueane | |
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ISSN
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0973-2063
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Publisher
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License
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This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |