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Title

 

 

 

 

 

Lysine richness in human snurps possible sites for electrophilic attacks

Authors

 

Sanjay Kumar Dey*, Sayak Ganguli, Protip Basu, Paushali Roy, Abhijit Datta

Affiliation

 

DBT-Centre for Bioinformatics, Presidency College, Kolkata

Email

 

sanjaydey23@gmail.com

 

Article Type

 

Hypothesis

Date

 

Received September 10, 2009; accepted November 14, 2009; published March 31, 2010

Abstract

Gene-expression strategies are remodeled following exposure to stress. The reactive oxidants and electrophiles generated after stress actually affects the structural and functional properties of different cellular proteins. It is also seen that lysine rich motifs of proteins play crucial role in electrophilic attack and modification. Therefore, this study revealing lysine richness in 5 main human snrups (Small Nuclear Ribonucleoproteins) indicates a possible mechanism of gene regulation under stress. This possibility is highly supported by the findings that surface residues of the molecules were full of lysine rich clusters. Lysine richness is also found to be a highly conserved pattern across the various domains of life indicative of stress adaptation in the prebiotic to biotic world transition. Moreover the modeled structures showed good all atom contacts and minimal outliers.

 

Keywords

Electrophiles, lysine, gene regulation, oxidative stress, snurps.

 

Citation

 

Dey et al., Bioinformation 4(9): 409-411 (2010)

Edited by

 

P. Kangueane

ISSN

 

0973-2063

 

Publisher

 

Biomedical Informatics

License

 

 

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.