BACK TO CONTENTS   |    PDF   |    PREVIOUS   |    NEXT

Title

 

 

 

 

 

Clustering tendency in the protein fold space

Authors

 

Oliviero Carugo

Affiliation

Department of General Chemistry, Pavia University, viale Taramelli 12, I-27100 Pavia, Italy and Department of Biomolecular Structural Chemistry, MFPL - Vienna University, Campus Vienna Biocenter 5, A-1030 Vienna, Austria

 

Email

 

oliviero.carugo@univie.ac.at

Article Type

 

Hypothesis

Date

 

Received June 20, 2009; Accepted July 23, 2009; Published February 28, 2010

Abstract

Several non-redundant ensembles of protein three-dimensional structures were analyzed in order to estimate their natural clustering tendency by means of the Cox-Lewis coefficient. It was observed that, despite proteins tend to aggregate into different and well separated groups, some overlap between different clusters occurs. This suggests that classifications bases only on structural data cannot allow a systematic classification of proteins. Additional information are in particular needed in order to monitor completely the complex evolutionary relationships between proteins.

 

Keywords

Cluster analysis; Clustering tendency; Protein fold; Protein structural domains; Protein structure classification.

 

Citation

 

Carugo, Bioinformation 4(8): 347-351 (2010)

Edited by

 

P. Kangueane

 

ISSN

 

0973-2063

 

Publisher

 

Biomedical Informatics

License

 

 

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.