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Title
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Comparative study of antioxidants as cancer preventives through inhibition of HIF-1 alpha activity
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Authors
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Jyoti Upadhyay, Rajesh K. Kesharwani, Krishna Misra*
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Affiliation
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Indian Institute of Information Technology, Allahabad, India-211002
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Article Type
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Hypothesis
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Date
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Received May 15, 2009; Revised June 18, 2009; Accepted November 15, 2009; Published December 06, 2009
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Abstract |
HIF-1 α (hypoxia inducible factor-1 α isoform) has been exploited as a target in cancer therapeutics. HIF-1 α is the isoform-2 of HIF-1 α subunit. It is a 735 residues long protein modeled in this study. The HIF-1 α is absolutely critical for continued survival of cancer cells as it is involved in the activation of glycolysis and it helps an oxygen-starved cell convert sugar to energy without using oxygen. It also initiates angiogenesis to bring in a fresh oxygen supply. HIF-1 α operates only in presence of free radicals. In the present study, five antioxidants, namely lycopene, ascorbic acid, α-tocopherol, curcumin and curcumin dipiperoyl ester which are potent scavengers of reactive oxygen species (ROS) have been docked to HIF-1 α modeled protein in order to assess their binding and consequently, their inhibitory activity. The binding energy score has been found to be in the order, curumin dipiperoyl ester > lycopene > curcumin > tocopherol > ascorbic acid. However, subsequent experiments should be designed to validate these observations.
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Citation
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Received May 15, 2009; Revised June 18, 2009; Accepted November 15, 2009; Published December 06, 2009 | |
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Edited by
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P. Kangueane
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ISSN
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0973-2063
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Publisher
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License
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This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |