Title

Abyssinones and related flavonoids as potential steroidogenesis modulators

Authors

Kaushik S. Hatti, Latha Diwakar, G. Venkateswara Rao, Anil Kush, G. Chandrasekara Reddy*

Affiliation

Vittal Mallya Scientific Research Foundation, PB No 406, K.R. Road; Bangalore 560004, India

Email

gcreddy@vmsrf.org

Article Type

hypothesis

Date

received February 19, 2009; revised April 8, 2009; accepted May 11, 2009; published June 28, 2009

Abstract

Abyssinones and related flavonoids were screened against 3 enzymes (3βHSD, 17βHSD and Aromatase) of steroidogenesis pathway. The virtual screening experiment shows high affinity for flavonones than their respective chalcones. A 4’ –OH blocked prenylated flavonone 2b (2-(2’, 2’-dimethyl chroman-6’-yl)-7-hydroxy chroman-4-one) had consistent binding affinity to all the three enzymes used in this study showing higher binding affinity to aromatase. A good correlation was observed between cytotoxic data (MCF-7, breast cancer cell line) and docking results indicating flavonone as a better steroidogenesis modulator in hormone dependent cancer.

Keywords

flavonoids; steoidogenesis modulators; docking; model; cancer

Citation

Hatti et al, Bioinformation 3(9): 399-402 (2009)

Edited by

P. Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.