Title

Towards the interaction mechanism of tocopherols and tocotrienols (vitamin E) with selected metabolizing enzymes

Authors

Jyoti Upadhyay and Krishna Misra

Affiliation

Indian Institute of Information Technology, Allahabad - 211 002; India

Email

krishnamisra@hotmail.com

Article Type

Hypothesis

Date

received October 15, 2008; revised November 22, 2008; accepted December 01, 2008; published April 21, 2009

Abstract

Vitamin E is a mixture of eight compounds α, β, γ, δ- tocopherols and α, β, γ, δ- tocotrienols. Their individual role in cellular transport as antioxidants and in metabolic pathways has been highlighted in the present work. All the eight compounds have been docked with the respective metabolizing enzymes (α-tocopherol transfer protein (ATTP), α-tocopherol associated protein (TAP), P-glycoprotein (P-gly) and human serum albumin (HSA)) to understand molecular interactions for pharmacokinetics. These have been structurally aligned against the four human phospholipids in order to reveal their individual role in chylomicron formation and hence the mechanism of cellular transport. The study of their binding with their metabolizing enzymes provides insight to the comparative antioxidant activity of each of these isomers.

Keywords

docking data; vitamin E, enzymes, mechanism; anti-oxidant

Citation

Upadhyay & Misra, Bioinformation 3(8): 326-331 (2009)

Edited by

P. Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.