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Title |
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Alzheimer's disease and HIV associated dementia related genes: I. location and function
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Authors |
Paul Shapshak1, 2, *, Hector E. Rodriguez3, Rajarathinam Kayathri 4, Andrew Levine5, Francesco Chiappelli6, Alireza Minagar7, 8
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Affiliation |
1Division of Infectious Diseases, Department of Internal Medicine, 2Department of Psychiatry and Behavioral Medicine, University of South Florida, College of Medicine, Tampa, FL 33613; 3Department of Biology, University of Miami, Coral Gables, FL 33146; 4Biomedical Informatics, 17A IrulaN Sundai Annex, Pondicherry 607 402, India; 5Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90024; 6Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095; 7Department of Neurology, 8Department of Psychiatry, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71130
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Phone |
813 844 8903
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Fax |
813 844 7605; * Corresponding author
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Article Type |
Hypothesis
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Date |
received April 29, 2008; accepted May 06, 2008; published May 29, 2008 | |
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Abstract |
Alzheimer's disease (AD), the most common cause of dementia, has few clinical similarities to HIV-1-associated dementia (HAD). However, genes were identified related among these dementias. Discovering correlations between gene function, expression, and structure in the human genome continues to aid in understanding the similarities between pathogenesis of these two dementing disorders. The current work attempts to identify relationships between these dementias in spite of their clinical differences, based on genomic structure, function, and expression. In this comparative study, the NCBI Entrez Genome Database is used to detect these relationships. This approach serves as a model for future diagnosis and treatment in the clinical arena as well as suggesting parallel pathways of disease mechanisms. Identifying a correlation among expression, structure, and function of genes involved in pathogenesis of these dementing disorders, may assist to understand better their interaction with each other and the human genome.
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Keywords |
Alzheimer’s disease (AD); HIV Associated dementia (HAD); gene function, expression; structure; human genome
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Citation |
Shapshak et al., Bioinformation 2(8): 348-357 (2008)
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Edited by |
P. Kangueane
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ISSN |
0973-2063
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Publisher |
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Copyright |
Publisher
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Copyright Transfer Agreement |
The authors of published articles in Bioinformation automatically transfer the copyright to the publisher upon formal acceptance. However, the authors reserve right to use the information contained in the article for non commercial purposes.
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License |
This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
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