Title

Role of thymine in protein coding frames of mRNA sequences

Authors

Perumal Anandagopu¹, Sivakumar Suhanya², Veerasamy Jayaraj¹ and Ekambaram Rajasekaran^1, *

Affiliation

¹Department of Biotechnology, Periyar Maniammai University, Thanjavur, Tamil Nadu-613403, India; ²Bharathidasan University, Tiruchirapalli, Tamil Nadu-620024, India

Email

ersekaran@gmail.com; * Corresponding author

Article Type

Hypothesis

Date

received December 31, 2007; revised March 15, 2008; accepted April 07, 2008; published April 19, 2008

Abstract

Distribution of thymine in protein coding mRNA sequences has been studied here.  Our study suggest that thymine in protein coding sequences are not randomly distributed but with probability. Frame1 prefers to have definite amount of thymine. It is observed that the thymine content of frame 4 is also involved in protein coding. Frame 3 prefers to have least amount of thymine. However, frame 2 and frame 6 shows a variable degree of thymine content. The mRNA sequences of heterosexual animals, particularly, the human show a different distribution profile (less thymine in frame 1) compared to that of yeast and plants.

Keywords

frame analysis; thymine distribution; sequence analysis; protein stability

Citation

Anandagopu et al., Bioinformation 2(7): 304-307 (2008)

Edited by

P. Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.