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Title |
Identification of a casein kinase II phosphorylation domain in NS1 protein of H5N1 influenza virus
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Authors |
Tamanna Anwar and Asad U Khan*
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Affiliation |
Interdisciplinary Biotechnology Unit Aligarh Muslim University, Aligarh 202002 India
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| Phone |
+91-571-2723088
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| Fax |
+91-571-2721776; * Corresponding author
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Article Type |
Hypothesis
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Date |
received June 19, 2007; revised September 05, 2007; accepted September 13, 2007; published online October 03, 2007
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Abstract |
Influenza virus causes febrile respiratory illness. The infection results in significant mortality, morbidity and economic disruption. In this bioinformatics study, we used the NS1 (the conserved nonstructural) protein of influenza A virus to demonstrate its role in infectivity. Our in silico study revealed a new Casein kinase II (CKII) phosphorylation domain at position 151-154. This domain was formed due to the mutation at position 151 (T151I). Moreover, considerable difference in the secondary structure of this protein due to mutation was also reported. The secondary structure prediction result is given at http://www.geocities.com/amubioinfo/InfluenzaAVirus.htm. It is also confirmed by contact residue analysis that the changes in secondary structure are due to mutations.
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Keywords
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nonstructural protein 1 (NS1); amino acid (AA); mutation; casein kinase II (CKII) phosphorylation
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Citation |
Anwar & Khan, Bioinformation 2(2): 57-61 (2007)
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Edited by |
M. Gollery
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |