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Title

 

 

 

 

Drug, dosage and activity studies of antimalarials by physical methods II

 

Authors

Vedam Rama Murthy1, Donkena Venkata Raghuram2,*, Pirala Narayana Murthy2
 

Affiliation

1T. J. P. S College (PG Courses), Guntur, Andhra Pradesh, India; 2Department of Physics, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh, India
 

Email

raghuramvenkat@yahoo.com; * Corresponding author

 

Article Type

Hypothesis

 

Date

received February 05, 2006; revised March 01, 2007; accepted April 13, 2007; published online May 20, 2007
 

Abstract

Studies pertaining to Drug-DNA interactions in treating a disease efficiently have taken an important place in recent times. Murthy et al were active in correlating the drug activity, with physical parameters like refractivity, susceptibility, molecular electron ionization cross-section and the dosage. The molecular polarizability αM, diamagnetic susceptibility χM and molecular electron ionization cross-section Q have been evaluated. An analysis of Q in the light of the data available on Plasma Protein Binding, Bio availability, Log p and Half-Life show semblance of regular dependence of Q on them and hence an effort is made to bring this dependence into a regular mathematical relationship.  The dosage of each drug is calculated. A critical look at the results arrived on Q and dosages reveal that a highly active drug with large Q need to be monitored in very small quantities and any minute increase in dosage is resulting in unwanted toxic effects and vice versa. The algebraic formulae enable one to calculate the dosages theoretically from the value of Q  and other parameters and the calculated dosage  through the formulae agreed favourably well with  suggested dosages. For example, in Primaquine Phosphate, the calculated dosage is 30mg/day against the suggested practical dosage of 26.3 mg/day.  A similar observation is made in Mepacrine with theoretical dosage of 60 mg/day as against the suggested practical dosage of 100 mg/ day. In short, the molecular structure followed by refraction and susceptibility measurements and Q will throw light on dosage, toxicity of a drug. Thus the present investigations pave way for a new direction of approach for study of drug activity without recourse to techniques involving highly expensive instrumentation and highly theoretical approaches involving quantum mechanical methods.

 

Keywords

 

drug; dosage; activity; anti-malarials

 

Citation

Murthy et al., Bioinformation 2(1): 12-16 (2007)

 

Edited by

P. Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.