Title
Molecular entities for the anti-melanoma effect of Solanum nigrum
Authors
Neha Sakharkar1,2, Ruchika Kaul-Ghanekar2, Yingying Song3 & Jian Yang4,*
Affiliation
1Bharati Vidyapeeth University, Pune - 411043, Maharashtra, India; 2Symbiosis School of Biological Sciences (SSBS), Symbiosis Centre for Research and Innovation (SCRI), Symbiosis International (Deemed University), Pune - 412115, Maharashtra, India; 3School of Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China; 4College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada; *Corresponding author
Neha Sakharkar - E - mail: sakharkar.neha@gmail.com
Ruchika Kaul-Ghanekar - E - mail: director_scri@siu.edu.in
Yingying Song - E - mail: 290362@njucm.edu.cn
Jian Yang - E - mail: jian.yang@usask.ca
Article Type
Research Article
Date
Received April 1, 2025; Revised April 30, 2025; Accepted April 30, 2025, Published April 30, 2025
Abstract
Prognosis for advanced and metastatic melanoma remains poor despite low incidence rate and early diagnosis. A significant number of melanoma patients use complementary and alternative medicines during their normal treatments in anticipating improving therapeutic efficacy. Solanum nigrum shows effective inhibitory activity against melanoma cells compared to Hedyotis diffusa, Scutellaria barbata, and Lobelia chinensis. Therefore, it is of interest to explore the anti-melanoma mechanism of S. nigrum. Our data show that three unique melanoma-related gene targets (CYP3A4, GBA2 and PTK6) for two unique active ingredients (diosgenin and solanocapsine) present in S. nigrum have potential role.
Keywords
Solanum nigrum; melanoma; unique active ingredient; unique targets; gene expression
Citation
Sakharkar et al. Bioinformation 21(4): 679-694 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
