Title

Management of oral sub-mucous fibrosis using platelet-rich plasma and triamcinolone with hyaluronidase

Authors

Ajay Kumar¹, Adit Srivastava¹, Neha Sah^2,*, Amlendu Shekhar¹, Sivani Darjee¹, Saumya Shukla¹, Vinayalekshmy IN Nair¹, Mahesh khairnar¹ &Ashutosh Kumar Rai¹

Affiliation

¹Department of Oral medicine and radiology, Institute of medical sciences Banaras Hindu University, Varanasi, Uttar Pradesh, India; ²Department of Dentistry, Maa Vindhyavasini Autonomous State Medical College, Mirzapur, Uttar Pradesh, India; *Corresponding author

Email

Ajay Kumar - E - mail: drajaysinghbhu@gmail.com
Adit Srivastava - E - mail: adit@bhu.ac.in
Nehasah - E - mail: dr.nehasah@gmail.com
Amlendu Shekhar - E - mail: amlenduss93@gmail.com
Sivani Darjee - E - mail: sivanibanu15@gmail.com
Saumya Shukla - E - mail: saumya95@gmail.com
Vinayalekshmy IN Nair- E - mail: vinayalekshmynair@gmail.com
Mahesh Khairnar - E - mail: kmahesh222@gmail.com
Ashutosh Kumar Rai - E - mail: ashutoshrai237@gmail.com

Article Type

Research Article

Date

Received April 1, 2025; Revised April 30, 2025; Accepted April 30, 2025, Published April 30, 2025

Abstract

Oral Submucous Fibrosis (OSMF) is a chronic, progressive and potentially malignant disorder of the oral mucosa, primarily associated with betel quid and areca nut chewing. Therefore, it is of interest to compare the efficacy of intralesional Platelet-Rich Plasma (PRP) versus triamcinolone acetonide with hyaluronidase in the treatment of oral submucous fibrosis. This is a randomized clinical trial was conducted at the unit of oral medicine and radiology, Faculty of Dental Sciences, IMS, Banaras Hindu University (BHU), Varanasi. Patients diagnosed with grade II and III oral submucous fibrosis participated in this study. Results show that intralesional PRP was more effective than the combination of triamcinolone acetonide and hyaluronidase in the management of oral submucous fibrosis.

Keywords

Oral submucous fibrosis (OSMF), platelet-rich plasma (PRP), triamcinolone acetonide, hyaluronidase, randomized clinical trial

Citation

Kumar et al. Bioinformation 21(4): 599-605 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.