Title
Regulation of inflammAging
Authors
Francesco Chiappelli1, 2*, Lily Fotovat3, Allen Khakshooy4, Oluwadayo Oluwadara5 & Jaden Penhaskashi6
Affiliation
1Dental Group of Sherman Oaks, Sherman Oaks, CA 91403 (www.oliviacajulisdds.com); 2UCLA Center for the Health Sciences, Los Angeles, CA 90095; 3Boston University, Boston, MA 02118; 4Department of Internal Medicine, Valley Hospital Medical Center, Las Vegas, NV 89106; 5Oluwadara Dental Corporation, 9612 East Foothill Blvd, Suite 100, Rancho Cucamonga, CA 91730; 6Division of West Valley Dental Implant Center, Encino, CA 91316; *Corresponding author
Francesco Chiappelli - E - mail: chiappelli.research@gmail.com
Lily Fotovat - E - mail: lilyfotovat@gmail.com
Allen Khakshooy - E - mail: akhakshooy@gmail.com
Oluwadayo Oluwadara - E - mail: ooluwadayo@oludent.org
Jaden Penhaskashi - E - mail: jadennpen@gmail.com
Article Type
Editorial
Date
Received April 1, 2025; Revised April 30, 2025; Accepted April 30, 2025, Published April 30, 2025
Abstract
The non-neuronal cholinergic system plays an important role in the modulation of immunity and in particular the control of the inflammatory response. The cholinergic anti-inflammatory pathway is mediated principally by the α7-nicotinic acetylcholine receptor (α7-nAChR) and its receptor-specific chaperone, resistance to inhibitors of cholinesterase (RIC)-3 chaperone protein. The point is made in this writing that therapeutic stimulation of the non-neuronal cholinergic system via, for instance, transcutaneous vagal stimulation, pharmaco-therapeutic activation of α7-nAChR/RIC-3, or stimulation of the pathway by other means, including microRNA treatment interventions could down-regulate states of inflammation such as the cytokines storm and chronic systemic inflammation in aging - viz, inflammAging. It is possible and even likely that controlling inflammAging by intervening on the non neuronal cholinergic system (NNCS) will be beneficial to a wide range of aging-related diseases, from type 2 diabetes and obesity to periodontal disease.
Keywords
Acetylcholine (ACh), non-neuronal cholinergic system (NNCS), α7 nicotinic acetylcholine receptor (α7-nAChR), cholinergic anti inflammatory pathway (CHAIP), resistance to inhibitors of cholinesterase-3 (RIC-3), MicroRNAs (miRs), inflammasome, pathogen associated molecular patterns (PAMPs), host cell-associated damage-associated molecular patterns (DAMPs), pattern recognition receptors (PRRs), nucleotide leucine-rich repeat-containing receptors (NLRs), pyrin "cell death fold" (PYD) domain, caspase activation and recruitment domain (CARD), nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR), cyclic GMP-AMP synthase linked to a stimulator of interferon genes (cGAS-STING), metalloproteinase-8 (MMP8)
Citation
Chiappelli et al. Bioinformation 21(4): 571-574 (2025)
Edited by
Francesco Chiappelli
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
