Title

Characterization of clear cell - Renal cell carcinoma using neutrophil - Lymphocyte ratio

Authors

S. Santhosh^{*, 1}, Poulose Chally², Abdul Azeez², Shrikant Patel³, Arifa Bakerywala⁴ & Heena Shaikh⁵

Affiliation

¹Department of Urology, Manipal Hospital Malleshwaram, Bengaluru, Karnataka, India; ²Department of Urology, Consultant, Baby Memorial Hospital, Calicut, Kerala, India; ³Private practitioner, Shree ram dental clinic and implant centre, Bhavnagar, Gujarat, India; ⁴Department of Pediatric dentistry, Tufts University School of Dental Medicine, United States of America; ⁵Department of Healthcare Leadership, Trinity Western University, Canada; *Corresponding author

Email

S Santhosh - E - mail: drsanthusri@gmail.com
Poulose Chally - E - mail: poulosechally@yahoo.co.in
Abdul Azeez - E - mail: drazeezav@gmail.com
Shrikant Patel - E - mail: shrikantpatelmds@gmail.com
Arifa Bakerywala - E - mail: arifa.mib@gmail.com
Heena Shaikh - E - mail: heenamshaikh.30@gmail.com

Article Type

Research Article

Date

Received March 1, 2025; Revised March 31, 2025; Accepted March 31, 2025, Published March 31, 2025

Abstract

The features of tumour in clear cell - renal cell carcinoma are evaluated using neutrophil - lymphocyte ratio for its prognosis. Hence, 186 clear cell-renal cell carcinoma patients with documented neutrophil lymphocyte ratio were obtained. Depending on the features of the lesion, patients underwent either a partial or radical nephrectomy and characteristics were studied in relation to normal or high neutrophil - lymphocyte ratio with a cut-off of 2.7. Of the 186 patients studied, 131 had a normal neutrophil lymphocyte ratio (<2.7), while 55 presented with an elevated neutrophil lymphocyte ratio (≥2.7). Elevated neutrophil lymphocyte ratio was significantly associated with both tumor size and renal vein invasion, with a p-value of less than 0.001. Thus, the neutrophil lymphocyte ratio is a valuable metric for assessing renal vein extension and predicting tumour size.

Keywords

Clear cell carcinoma, renal cell carcinoma, neutrophil-lymphocyte ratio, survival

Citation

Santhosh et al. Bioinformation 21(3): 499-503 (2025)

Edited by

Neelam Goyal & Shruti Dabi

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.