Title

Fentanyl versus dexmedetomidine during awake-fibreoptic intubation

Authors

Anirudh Jayaraj*, P.B Jamale & Vishwas Manohar Joshi

Affiliation

Department of Anesthesiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India; *Corresponding author

Email

Anirudh Jayaraj - E - mail: drjayarajanirudh4@gmail.com
P B Jamale - E - mail: jamalepb@gmail.com
Vishwas Manohar Joshi - E - mail: drjoshivm@gmail.com

Article Type

Research Article

Date

Received March 1, 2025; Revised March 31, 2025; Accepted March 31, 2025, Published March 31, 2025

Abstract

Awake-fiberoptic intubation is considered the gold standard technique for managing an anticipated difficult airway. Therefore, it is of interest to compare and evaluate fentanyl and dexmedetomidine on intubation conditions during awake-fiberoptic intubation. Hence, 90 patients were randomly divided into two groups, namely Group D and Group F, each consisting of 45 individuals. They were given Dexmedetomidine (1 mcg/kg over 10 minutes) and fentanyl (2 mcg/kg over 10 minutes) followed by monitoring and recording using Ramsay sedation scale at every 2 minutes, 5 minutes, 10 minutes and 20 minutes. Parameters like systolic blood pressure, diastolic blood pressure and heart rate were noted. They found that, the differences are not statistically significant as time advances following intubation, even though dexmedetomidine contributes to the maintenance of a lower systolic blood pressure. Further, the efficacy of dexmedetomidine in reducing diastolic blood pressure is more pronounced; however, following intubation, the disparities between the two groups diminish and it is not statistically significant. Thus, in comparison to fentanyl, dexmedetomidine demonstrates superior efficacy in the management of heart rate both during and immediately following intubation.

Keywords

Fentanyl, dexmedetomidine, intubation conditions, blood pressure, heart rate, systolic blood pressure, diastolic blood pressure

Citation

Jayaraj et al. Bioinformation 21(3): 418-425 (2025)

Edited by

Neelam Goyal & Shruti Dabi

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.