Title
Unveiling dickkopf-1 in periodontitis progression- A review
Authors
Bawatharani Maharavi, Jaideep Mahendra* & Prashanthi Prakash
Affiliation
Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, Tamilnadu, India; *Corresponding author
Bawatharani Maharavi - E - mail: 22212001@madch.edu.in; Phone: +91
9043365789
Jaideep Mahendra - E - mail: drjaideep.perio@madch.edu.in; Phone:
+91 9444963973
Prashanthi Prakash - E - mail: drprashanthi.perio@madch.edu.in;
Phone: +91 8610353897
Article Type
Review
Date
Received March 1, 2025; Revised March 31, 2025; Accepted March 31, 2025, Published March 31, 2025
Abstract
Periodontitis is a chronic bacterial infection causing tissue damage, bone loss and tooth mobility and thus, impacting quality of life. It is influenced by factors like plaque, genetics and immune response, driving inflammation and tissue destruction. Dickkopf-1 inhibits the wingless-related integration site (Wnt) signaling pathway, reducing osteoblast activity and promoting osteoclast formation, leading to bone resorption. Neutralizing Dickkopf-1 activity may facilitate bone regeneration, suggesting its potential as a target for periodontitis treatment. Therefore, it is of interest to review the role of Dickkopf-1 in periodontitis for understanding its impact on alveolar bone resorption highlighting its therapeutic potential in improving alveolar bone health.
Keywords
Inflammation, periodontitis, alveolar bone, dickkopf protein, wingless-related integration site (Wnt) signaling pathway
Citation
Maharavi et al. Bioinformation 21(3): 365-368 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
