Title
Role of microRNAs in chronic hepatitis E viral infection
Authors
Zoya Shafat, Murshad Ahmed, Anam Farooqui, Nazim Khan & Shama Parveen*
Affiliation
Department of Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India; *Corresponding author
Zoya Shafat - E - mail: zoya179695@st.jmi.ac.in
Murshad Ahmed - E - mail: murshad60ali@gmail.com
Anam Farooqui - E - mail: anam169157@st.jmi.ac.in
Nazim Khan - E - mail: nazim2206031@st.jmi.ac.in
Shama Parveen - E - mail: sparveen2@jmi.ac.in
Article Type
Research Article
Date
Received February 1, 2025; Revised February 28, 2025; Accepted February 28, 2025, Published February 28, 2025
Abstract
Hepatitis E virus (HEV) is an emerging zoonotic pathogen and it is associated with chronic hepatitis E virus infection (CHE) in immuno-suppressed patients due to failure of viral clearance. A network of the CHE-associated-differentially expressed genes (DEGs) is known. Hence, a comprehensive assessment of the known protein-protein interaction (PPI) network is of interest. After network clustering, the hub gene-associated microRNAs (miRNAs) were explored and subsequently, these identified miRNAs (miR-129-2-3p, miR-130a-3p, miR-138-5p, miR-212-3p, miR-221-3p, miR-27b-3p and miR-29c-3p) were undertaken for enrichment analysis. It should be noted that these miRNAs are significantly associated with Hepatitis E virus infection for further validation and analysis.
Keywords
Hepatitis E virus, chronic hepatitis E virus infection, network topology, module detection, mRNA-miRNA network, key miRNAs, enrichment analysis
Citation
Shafat et al. Bioinformation 21(2): 240-252 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
