Title

Hepatic dysfunction among scrub typhus Indian patients with acute undifferentiated febrile illness

Authors

Sourabh Dwivedi^1,*, Kapila Gaikwad¹, Yar Mohammad Ansari¹, Pratiksha Pandey Dwivedi² & Shikhar Sharma³

Affiliation

¹Department of Biochemistry, Shyam Shah Medical College, Rewa, Madhya Pradesh, India; ²Department of Microbiology, Rajmata Shrimati Devendra Kumari Singhdeo Government Medical College, Ambikapur, Chhattisgarh, India; ³Department of Community Medicine, Shyam Shah Medical College, Rewa, Madhya Pradesh, India; *Corresponding author

Email

Sourabh Dwivedi - E - mail: sourabhdwived96@gmail.com

Kapila Gaikwad - E - mail: drkapila27@gmail.com

Yar Mohammad Ansari - E - mail: dryaransari724@gmail.com

Pratiksha Pandey Dwivedi - E - mail: pratikshapandey3090@gmail.com

Shikhar Sharma - E - mail: shikhary2j@hotmail.com

Article Type

Research Article

Date

Received February 1, 2025; Revised February 28, 2025; Accepted February 28, 2025, Published February 28, 2025

Abstract

Scrub typhus is a febrile illness caused by through trombiculid mite, bite Orientia tsutsugamushi. It is often unrecognized due to its vague symptoms. It is prevalent in the Rewa region of Madhya Pradesh, India. Therefore, it is of interest to assess hepatic dysfunction and to establish the association between liver function test parameters and disease severity in confirmed Scrub typhus cases. Hence, 50 IgM ELISA positive cases from July to September 2024 at Shyam Shah Medical College, Rewa were studied. Data were analyzed using IBM SPSS 25 software, with Spearman’s correlation used to relate severity, liver function test parameters and fever duration. The average fever duration was 6.22 days, with 80% of patients showing serum glutamate oxaloacetate transaminase and 70% showing serum glutamate pyruvate transaminase abnormalities. Thus, there was a correlation between disease severity and liver dysfunction, with moderate injury in 62% and severe injury in 38% of patients.

Keywords

Scrub typhus, hepatic dysfunction, acute liver failure, age group, days of fever

Citation

Dwivedi et al. Bioinformation 21(2): 137-144 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.