Title

Challenges in chemotherapy for head and neck cancer: A review

Authors

Richa Wadhawan^1,*, Akansh Datta², Sita Gogula³, Anand Krishnan³, Dinesh Kumar Yadav⁴ & Tarun Choudhary⁵

Affiliation

¹Department of Oral Medicine, Diagnosis & Radiology, PDM Dental College & Research Institute, Bahadurgarh, Haryana, India; ²Department of Oral and Maxillofacial Surgery, Teerthanker Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India; ³Department of Oral Medicine and Radiology, Lincoln University College, Petaling Jaya, Selangor, Malaysia; ⁴Department of Oral Pathology, Lincoln University College, Petaling Jaya, Selangor, Malaysia; ⁵Department of Oral and Maxillofacial Surgery, Government Dental College, Jodhpur, Rajasthan, India; *Corresponding author

Email

Richa Wadhawan - E - mail: wadhawanricha1@gmail.com

Akansh Datta - E - mail: drakansh.dental@tmu.ac.in

Sita Gogula - E - mail: sita.89513@gmail.com

Anand Krishnan - E - mail: anandkrishnadr@gmail.com

Dinesh Kumar Yadav - E - mail: yadunandan.dinesh@gmail.com

Tarun Choudhary - E - mail: drtarunchoudhary@gmail.com

Article Type

Review

Date

Received February 1, 2025; Revised February 28, 2025; Accepted February 28, 2025, Published February 28, 2025

Abstract

Head and neck cancer (HNC) remains a global health challenge due to its high mortality and morbidity. Advances in chemotherapy, combination therapies, and targeted treatments like immunotherapy, have significantly improved survival rates. These developments pave the way for personalized therapies that maximize effectiveness while minimizing toxicities. However, challenges such as tumor resistance, treatment-related side effects and limited access to advanced therapies continue to hinder progress. Addressing these issues requires efforts in clinical research, biomarker discovery and ensuring equitable access to innovative treatments worldwide.

Keywords

Head and neck squamous cell carcinoma, chemotherapy, cisplatin, immunotherapy, clinical trials, combination therapy

Citation

Wadhawan et al. Bioinformation 21(2): 121-126 (2025)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.