Title
Lactate dehydrogenase (LDH) as an indicator of pre-eclampsia
Authors
Kapil Raghuwanshi1, Bhupesh Kushram2, Dileep Dandotiya3, Sudhakar Petkar4, Swapnali Tambade5 & Mahendra Gandhe6,*
Affiliation
1Department of Biochemistry, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India; 2Department of Surgery, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India; 3Department of Community Medicine, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India; 4Department of Biochemistry, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India; 5Department of Dentistry, Chhindwara Institute of Medical Sciences, Madhya Pradesh, India; 6Department of Biochemistry, Chhindwara Institute of Medical Sciences, Chhindwara, Madhya Pradesh, India; *Corresponding author
Kapil Raghuwanshi - E - mail: drkapilraghuwanshi28@gmail.com; Phone: +91 7000060357
Bhupesh Kushram - E - mail: kushrsmbhupesh@gmail.com; Phone: +91 9981477452
Dileep Dandotiya - E - mail: dr.dileep85@yahoo.com; Phone: +91 7389675415
Sudhakar Petkar - E - mail: sudhakar9964@gmail.com; Phone: +91 9827714800
Swapnali Tambade - E - mail: swapnalit5@gmail.com; Phone: +91 7694852825
Mahendra Gandhe - E - mail: drmahendragandhe@gmail.com; Phone: +91 9944723532
Article Type
Research Article
Date
Received February 1, 2025; Revised February 28, 2025; Accepted February 28, 2025, Published February 28, 2025
Abstract
High blood pressure (higher than 140/90 mm Hg), proteinuria and swelling due to fluid retention are symptoms of preeclampsia, a disease that affects pregnant women after the 20th week of pregnancy. The cytoplasm of cells undergoing anaerobic glycolysis contains the enzyme lactate dehydrogenase or LDH. Therefore, it is of interest to ascertain the blood lactate dehydrogenase levels of pre-eclamptic women, to assess and analyze these levels, to compare lactate dehydrogenase levels in different groups of preeclampsia patients and healthy controls, and to examine the role of lactate dehydrogenase in preeclampsia severity ratings. Increased blood lactate dehydrogenase levels are associated with more severe preeclampsia, according to this study's results. Thus, it is crucial to determine lactate dehydrogenase levels in preeclamptic women early on so that these patients may get the right medicine and reduce the morbidity and mortality associated with these disorders.
Keywords
Preeclampsia, lactate dehydrogenase, placental hypoxia
Citation
Raghuwanshi et al. Bioinformation 21(2): 116-120 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
