Title

Identification of key candidates associated with chronic hepatitis E virus infection

Authors

Zoya Shafat¹, Anam Farooqui¹, Naaila Tamkeen², Nazim Khan¹, Asimul Islam¹ & Shama Parveen^1,*

Affiliation

¹Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India; ²Department of Biosciences, Jamia Millia Islamia, New Delhi, India; *Corresponding author

Email

Zoya Shafat - E - mail: zoya179695@st.jmi.ac.in

Anam Farooqui - E - mail: anam169157@st.jmi.ac.in

Naaila Tamkeen - E - mail: naaila179739@st.jmi.ac.in

Nazim Khan - E - mail: nazim2206031@st.jmi.ac.in

Asimul Islam - E - mail: aislam@jmi.ac.in

Shama Parveen - E - mail: sparveen2@jmi.ac.in

Rajan Patel - E - mail: rpatel@jmi.ac.in

Article Type

Research Article

Date

Received January 1, 2025; Revised January 31, 2025; Accepted January 31, 2025, Published January 31, 2025

Abstract

An in-depth understanding into recent development and management of chronic hepatitis E virus (HEV) infection (CHE) is of interest as the underlying molecular mechanisms remain unexplored. The novel analysis conducted on the mRNA expression profile revealed a total of 69, 157 and 411 specific DEGs for mild, moderate and severe HEV, respectively. Interestingly, we found upregulated expression levels of 8 genes BATF2, OASL, IFI44L, IFIT3, RSAD2, IFIT1, RASGRP3 and IFI27, which shows their association with persistent HEV infection. Of these genes, 6 (OASL, IFI27, IFIT1, IFIT3, RSAD2 and IFI44L) made into the PPI network and were common at each stage of infection. This provides insights into these identified key genes and pathways which could be targeted to offer better interventions for CHE in future biological research.

Keywords

Hepatitis E virus, chronic hepatitis E virus infection, differentially expressed genes, enrichment analysis and protein-protein interaction network

Citation

Shafat et al. Bioinformation 21(1): 66-77 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.