Title

Linking serum leptin and tyroid stimulating hormone among metabolic syndrome patients with and without hypothyroidism

Authors

Barla Krishna¹, Priya K. Dhas^1,* & Veluri Ganesh²

Affiliation

¹Department of Biochemistry, Vinayaka Mission's Kirupananda Variyar Medical College and Hospitals, Vinayaka Mission's Research Foundation (Deemed to the University), Salem, Tamil Nadu, India; ²Department of Biochemistry, PES University Institute of Medical Sciences and Research, PES University, Bangalore – 560100, Karnataka, India; *Corresponding author   

Email

Barla Krishna - E - mail: drkrishnabarla@gmail.com

Priya K. Dhas - E - mail: biochemvmkvmc@yahoo.com

Veluri Ganesh - E - mail: ganeshbabu370@gmail.com

Article Type

Research Article

Date

Received January 1, 2025; Revised January 31, 2025; Accepted January 31, 2025, Published January 31, 2025

Abstract

The comparison of thyroid profile and serum leptin levels among patients with metabolic syndrome who did not have hypothyroidism is of interest. Hence, we recruited 40 healthy controls and 80 patients with metabolic syndrome, 40 patients had hypothyroidism and 40 patients without hypothyroidism. Blood sugar levels, thyroid profiles, lipid profiles and serum leptin levels were measured and compared between the metabolic syndrome and control groups. The serum leptin levels of patients with hypothyroidism were considerably higher (P=0.0001**) when compared to metabolic syndrome patients without hypothyroidism and controls. Furthermore, there was a substantial positive correlation between these levels and thyroid stimulating hormone. Results show that serum leptin and TSH are significantly correlated among metabolic syndrome patients with and without hypothyroidism. Thus, monitoring of leptin levels among metabolic syndrome patients with and without hypothyroidism is relevant.

Keywords

Hypothyroidism, leptin, metabolic syndrome and thyroid stimulating hormone

Citation

Krishna et al. Bioinformation 21(1): 6-10 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.