Title
Plasma fibrinogen degradation products with salivary coagulopathy in OSMF among Indians
Authors
Kanika Sethi1, Narendra Nath Singh2 & Ankita Tandon*, 2
Affiliation
1Department of Oral Pathology and Microbiology, Inderprastha Dental College, Sahibabad, Ghaziabad, Uttar Pradesh, India; 2Department of Oral Pathology, Microbiology and Forensic Odontology, Dental Institute, RIMS, Ranchi, Jharkhand, India; *Corresponding author
Kanika Sethi - E - mail: drkanikasethi@gmail.com; Phone +91 8586966406
Narendra Nath Singh - E - mail: naren_cancer@hotmail.com; Phone +91 9837027721
Ankita Tandon - E - mail: drankitatandon7@gmail.com; Phone +91 9891987040
Article Type
Research Article
Date
Received August 1, 2024; Revised August 31, 2024; Accepted August 31, 2024, Published August 31, 2024
Abstract
Oral submucous fibrosis (OSMF) produces changes localized to oral cavity. Hence, it is reasonable to assume that saliva may have an important role in its etiology. This prospective case control study included 37 patients with OSMF which were compared with age and gender matched healthy controls. Salivary coagulopathy procedures as described by Chatuvedi et al. and quantification of plasma fibrinogen degradation products using a commercially available kit were carried out. The obtained data was analyzed using Chi-square tests and Tukey HSD test. The salivary coagulopathy was strongly indicated in saliva of OSMF patients and was dependent on the severity of disease. There were also increased levels of plasma fibrinogen degradation products compared to the controls and were found to have a statistically significant correlation with increasing clinical grades of oral submucous fibrosis (p≤ 0.05)
Keywords
Oral submucous fibrosis, salivary coagulopathy, fibrinogen degradation products.
Citation
Sethi et al. Bioinformation 20(8): 829-836 (2024)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
