Serum iron, zinc and copper among Indian patients with leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma

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Title	Serum iron, zinc and copper among Indian patients with leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma
Authors	Pratibha Kavle¹, Rashi Dubey², Annaluru Sri Sasank Tejaswee³, Gunmeek Kaur⁴, Animesh Mondal⁵, Vishal D Patel⁶, Keyur Jitendrakumar Patel⁷ & Ansee Rameshbhai Vaghani⁸
Affiliation	¹Department of Oral Pathology, Bharati Vidyapeeth (Deemed to be University) dental college and hospital, Navi Mumbai, India; ²Department of Pedodontics and Preventive Dentistry, SharadPawar Dental College and Hospital(DattaMegheInstitute of Higher Education and Research (Deemed to be a University), Sawangi, Wardha, Maharashtra, India; ³Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Science, KIIT Deemed to Be University, Bhubaneswar, Odisha, India; ⁴Department of Oral and Maxillofacial Surgery, LuxmiBai Dental College and Hospital, Patiala. ⁵Deptartment of Oral and Maxillofacial Pathology, Dr.R.Ahmed Dental College & Hospital, Kolkata.⁶Department of Orthodontics and Dentofacial Orthopaedic, Dhramsinh Desai University, Nadiad, Gujarat, India. ⁷Government Medical College Surat, Gujarat, India; ⁸Department of Oral Pathology and Microbiology, Manubhai Patel Dental College, Vadodara, India; *Corresponding author
Email	Pratibha Kavle - E-mail: pratibhakavle@gmail.com Rashi Dubey - E-mail: rashidubey0186@gmail.com Annaluru Sri SasankTejaswee - E-mail: sasankannaluru@gmail.com Gunmeek Kaur - E-mail: gunmeekkaur@gmail.com Animesh Mondal - E-mail: animeshmondal106@gmail.com Vishal D Patel- E-mail: drvishalortho@gmail.com Keyur Jitendrakumar Patel - E-mail: drkeyurpatel22sep@gmail.com Ansee Rameshbhai Vaghani - E-mail: Avagh708@gmail.com
Article Type	Research Article
Date	Received June 1, 2024; Revised June 30, 2024; Accepted June 30, 2024, Published June 30, 2024
Abstract	The serum levels of iron, zinc and copper in patients with leukoplakia, oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) and compare them with normal subjects is of interest to dentists. The effort was to determine a parameter that will aid the initial diagnosis, a more efficient therapy plan, and ultimately a better prognosis. Participants in the study comprised 40 healthy normal volunteers, 60 patients diagnosed with leukoplakia, 60 patients diagnosed with OSCC, and 60 patients diagnosed with OSMF. After fasting for the whole night, blood samples were taken from each participant. There was analysis by inductively coupled plasma-optical emission spectrometry (ICP-OES) for the determination of trace elements; iron, copper, and zinc. The serum levels of iron and zinc in normal subjects was greater as compared to patients with leukoplakia, OSMF and OSCC. There was increase in serum copper levels in patients with oral leukoplakia, OSMF and OSCC as compared with normal subjects.
Keywords	OSMF, Leukoplakia, OSCC, serum, iron, zinc, copper.
Citation	Kavle et al. Bioinformation 20(6): 660-664 (2024)
Edited by	Dr. Vini Mehta MDS
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.