Title
Estimation of depression, anxiety and serum cortisol in patients with oral lichen planus, leukoplakia and oral submucous fibrosis
Authors
Nagaraja A1,*, Yusra Khan2, Dheeraj Sharma3, Neeraj Sharma4, Ranjeeta Mehta5& Sameer Gupta6
Affiliation
1Department of Oral & Maxillofacial Pathology and Oral Microbiology, Seema Dental College & Hospital, Rishikesh, Uttarakhand, India; 2Department of Oral & Maxillofacial Pathology and Oral Microbiology, Faculty of Dentistry, Jamia Millia Islamia University, New Delhi, India; 3Department of Oral & Maxillofacial Pathology and Oral Microbiology, Index Institute of Dental Sciences, Indore, M.P., India; 4Departmentof Prosthodontics, Modern Dental College & Research centre, Indore, M.P., Indore, India; 5DepartmentofOral Medicine & Maxillofacial Radiology, Seema Dental College & Hospital, Rishikesh, Uttarakhand, India; 6Department of Oral & Maxillofacial Surgery, Inderprastha Dental College and Hospital, Ghaziabad, Uttar Pradesh, India; *Corresponding author
Nagaraja A - E-mail: nagsdoc@gmail.com
Yusra Khan - E-mail: ykhan@jmi.ac.in
Dheeraj Sharma - E-mail: drdheeraj25@gmail.com
Neeraj Sharma - E-mail: drneeraj22@gmail.com
Ranjeeta Mehta - E-mail: ranjeetamehta20@gmail.com
Sameer Gupta - E-mail: sameer.gupta83@yahoo.in
Article Type
Research Article
Date
Received June 1, 2024; Revised June 30, 2024; Accepted June 30, 2024, Published June 30, 2024
Abstract
Stress and anxiety may be found in patients with oral submucous fibrosis (OSMF), oral leukoplakia (OL) and oral lichen planus (OLP). Cortisol, sometimes referred to as the "stress hormone," has been employed as a stress predictor. Therefore, it is of interest to estimate the levels of depression, anxiety and serum cortisol and establish correlation between them in patients with OL.OLP and OSMF. There were 240 patients, aged 20 years to 45 years, who were divided into four categories (OL, OSMF, OLP and control) of 60 patients apiece. In the supervision of a psychiatrist, the Hamilton Depression Rating Scale (HAM D) and Hamilton Anxiety Rating Scale (HAM (A) questionnaires were filled out. Five millilitres of venous blood were extracted using standard aseptic technique, and all of the samples were examined for serum cortisol level. Anxiety and depression was found in subjects of OL, OSMF and OLP at advanced stages. It was inferred that serum cortisol level was statistically correlated with depression and anxiety in patients with OL, OSMF and OLP.
Keywords
anxiety, depression, cortisol, Oral leukoplakia, oral lichen planus, OSMF
Citation
Nagaraja et al. Bioinformation 20(6): 655-659 (2024)
Edited by
Dr. Vini Mehta MDS
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
