Title
Cytotoxicity and molecular docking analysis of phytochemicals from Vallisneria spiralis with protein target 3CZH in breast cancer management
Authors
Ravindra Waykar* & Srinivasakumar Kumarapillai*
Affiliation
Department of Pharmacy, Lincoln University College, Wisma Lincoln, No. 12-18, Jalan SS 6/12, 47301 Petaling Jaya, Selangor Darul Ehsan, Malaysia; *Corresponding author
Ravindra Waykar - E - mail: ravindra@lincoln.edu.my
Srinivasakumar Kumarapillai - E - mail: srinivasakumar@lincoln.edu.my
Article Type
Research Article
Date
Received December 1, 2024; Revised December 31, 2024; Accepted December 31, 2024, Published December 31, 2024
Abstract
The anticancer potential of Vallisneria spiralis Linnaeus (Vallisneria spiralis L.) for human breast cancer management is of interest. In vitro shows that increasing concentrations of Vallisneria spiralis silver nanoparticles (AgNPs) and iron oxide nanoparticles (IONPs) resulted in greater cytotoxicity against MCF-7 breast cancer cells. The antioxidant potential of Vallisneria spiralis L. was assessed using 2-diphenyl-1-picryl-hydroxyl (DPPH) radical scavenging assay. Further molecular docking analysis of phytocompounds from Vallisneria spiralis L. with the target protein (PDB ID: 3CZH) shows optimal binding features. Thus, cytotoxicity analysis of Vallisneria spiralis for breast cancer with molecular docking of its phytochemicals and a target protein 3CZH is reported for further consideration.
Keywords
Vallisneria spiralis Linnaeus, breast cancer, Silver nanoparticles (AgNPs), Iron oxide nanoparticles (IONPs), in silico analysis, in vitro analysis
Citation
Received December 1, 2024; Revised December 31, 2024; Accepted December 31, 2024, Published December 31, 2024
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
