Title

Assessing the efficacy of intraoperative fluorescence imaging for tumor margin identification in breast conserving surgery

Authors

Pritika Gnanasekaran¹, Niraj Balakrishnan², Navaneeth Ranjith³, Rakshana Munusamy⁴ & Naveen Bose J^5,*

Affiliation

¹Department of Medicine, Global Medical Centre, Salem, Tamil Nadu, India; ²Department of Surgery, SRM Medical College, Chennai, Tamil Nadu, India; ³Department of Urology, Caritas Hospital, Kottayam, Kerala, India; ⁴Department of Surgery, Madurai Medical College, Madurai, Tamil Nadu, India; ⁵Department of Emergency Medicine, Madurai Medical College, Madurai, Tamil Nadu, India; *Corresponding author

Email

Pritika Gnanasekaran - E - mail: prithika33378@gmail.com; Phone no: +91 9500631112

Niraj Balakrishnan - E - mail: niraj54321@gmail.com; Phone no: +91 9600113191

Navaneeth Ranjith - E - mail: navu93@gmail.com; Phone no: +91 7736415446

Rakshana Munusamy - E - mail: rakshanamunisamy248@gmail.com; Phone no: +91 7397503059

Naveen Bose J - E - mail: naveenbose.j@gmail.com; Phone no: +44 7900172754, +91 7010889096

Article Type

Research Article

Date

Received December 1, 2024; Revised December 31, 2024; Accepted December 31, 2024, Published December 31, 2024

Abstract

Breast-conserving surgery (BCS) aims to remove malignant breast tissue while preserving healthy tissue, with clear margins crucial for reducing recurrence and avoiding additional surgeries. This study evaluated the effectiveness of intraoperative fluorescence imaging (IFI) in achieving negative margins compared to standard intraoperative techniques in 100 retrospectively analyzed patients. IFI-assisted BCS achieved negative margins in 88% of cases versus 65% with standard methods (p < 0.001) and significantly reduced re-excision rates (8% vs. 22%, p = 0.002). Long-term recurrence rates over 12 months were similar between the groups (p = 0.145). These findings suggest that IFI enhances margin visualization, reduces re-excisions, and serves as a valuable adjunct to traditional techniques in BCS.

Keywords

Breast-conserving surgery, fluorescence imaging, tumor margins, breast cancer, re-excision, intraoperative imaging.

Citation

Gnanasekaran et al. Bioinformation 20(12): 1927-1930 (2024)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.