Title

Exploring the gut-heart axis: A prospective analysis of microbiota in cardiovascular health

Authors

Deepika Gnanasekaran¹, Aadhithya Raaj Pandurangan², Pradeepan Sengiah Ramaswamy², Shrunga Kandhi Raghavendra³, Karthick Raman⁴ & Gowri Shankar Somasundaram^2,*

Affiliation

¹Department of Internal Medicine, Hillingdon Hospital, Uxbridge, London, United Kingdom; ²Department of Internal Medicine, Madras Medical College, Chennai, Tamil Nadu, India; ³Department of Internal Medicine, Chamarajanagar Institute of Medical Sciences (CIMS), Kasaba Hobli, Chamarajanagar, Karnataka, India; ⁴Department of Cardiology, Government Sivagangai Medical College Hospital, Sivagangai, Tamil Nadu, India; *Corresponding author

Email

Deepika Gnanasekaran - E - mail: deepekasekar@gmail.com; Phone no: +91 9445650840
Aadhithya Raaj Pandurangan - E - mail: aadhi.1pandu@gmail.com; Phone no: +91 7010815773
Pradeepan Sengiah Ramaswamy - E - mail: pradeepan.sengiah98@gmail.com; Phone no: +91 8825703795
Shrunga Kandhi Raghavendra - E - mail: shrungakr1999@gmail.com; Phone no: +91 9535357441
Karthick Raman - E - mail: drkarthickraman@gmail.com; Phone no: +91 9821597290
Gowri Shankar Somasundaram - E - mail: gowrishankar1518@gmail.com; Phone no: +91 9080262904

Article Type

Research Article

Date

Received December 1, 2024; Revised December 31, 2024; Accepted December 31, 2024, Published December 31, 2024

Abstract

The relationship between gut microbiota composition and the development of cardiovascular disease, with a potential role of microbial metabolites in inflammatory and metabolic pathways is of interest. We analyzed gut microbiota and markers of cardiovascular health in a cohort of 100 participants for three years to search for microbial signatures correlated with increased CVD risk. Our results show several correlations between specific microbial taxa, lipid metabolism, and systemic inflammation, whereby a higher Firmicutes/Bacteroides ratio is associated with a greater incidence of CVD. These results suggest that intervention targeting the microbiome has the potential to reduce risk for CVD and point towards a role for gut microbiota in cardiovascular health.

Keywords

Gut microbiota, cardiovascular disease, prospective study, lipid metabolism, inflammation, microbial signatures, microbiome interventions

Citation

Gnanasekaran et al. Bioinformation 20(12): 1900-1903 (2024)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.